Mfg Part Number
Ab00943-10.0
Vector Labs Ab00943-10.0 Anti-SERT [8B6], Human IgG1, kappa (200 μg)
Quick Overview
8B6 was produced by immunising SERT KO mice with residues 73-616 of wildtype human SERT. Hybridomas were generated using established protocols.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 8B6 |
| Synonyms: | SLC6A4; Sodium-dependent serotonin transporter; 5HT transporter; Solute carrier family 6 member 4; HTT; SLC6A4 |
| Amount: | 200 μg |
| Application Codes Clone: | Crystallisation |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 27049939 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The 8B6 Fab binds to extracellular loops 2 and 4 of hSERT, as shown by crystallography (Coleman et al, 2016). |
| Application Notes: | The 8B6 Fab fragment was crystallised in complex with human SERT to aid structure determination (Coleman et al, 2016). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |