Mfg Part Number
Ab00987-10.3
Vector Labs Ab00987-10.3 Anti-DR5 [304], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The antibody was raised in mice homozygous for both disrupted endogenous Ig heavy chain and k light chain, harboring a chromosome 14 fragment (SC20) containing a human Ig heavy chain locus and a human Igk chain transgene (KCo5). The mice were immunised against TRAIL-R1 and TRAIL-R2.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 304 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | TRAILR2; TNFRSF10B; TRAIL receptor 2; tumor necrosis factor receptor superfamily member 10B |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; theraputic; RIA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG4 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human IgG4 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | The antibody is specific to human DR5. |
| Application Notes: | This antibody has shown high anti-tumour activity in mice with subcutaneously transplanted colon carcinoma cells Colo205. It has tumour-specific cell-death-inducing activity alone in tissue culture so is expected to show anti-tumour activity independent of physiological conditions of the patient. The antibody has been shown to function in ELISA and RIA. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |