Mfg Part Number
Ab01016-23.0
Vector Labs Ab01016-23.0 Anti-PD-1H [MH5A], Rabbit IgG, lambda (200 μg)
Quick Overview
The antibody was generated by immunising Armenian hamsters with mPD-1HIg.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | MH5A |
| Synonyms: | VISTA; VISR; B7-H5; B7H5; GI24; PP2135; SISP1; DD1alpha; C10orf54; chromosome 10 open reading frame 54; V-set immunoregulatory receptor |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IHC; block; therapeutic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Hamster IgG format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody specifically binds PD-1H. |
| Application Notes: | The antibody has been labelled with biotin and used to stain formalin-fixed tissues from wild-type C57BL/6 mice at 6 weeks of age. This showed specific staining for PD-1H in the T cell zone and marginal zone. The antibody stains P815 cells transfected with full-length PD-1H plasmid, but not control plasmid. Antibody specificity has been confirmed by ELISA. A single 200-μg dose of MH5A prevented aGVHD in mouse models, caused a reduction in accumulation and expansion of CD8+ and CD4+ T cells in spleens and livers and greatly reduced numbers of inflitrating T cells in all aGVHD target tissues examined. Few mAbs targeting a single cosignalling molecule have such a potent preventative effect (Flies D et al, 2011). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |