JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Skip to the beginning of the images gallery

Mfg Part Number

Ab01018-1.69

Vector Labs Ab01018-1.69 Anti-CTLA-4 [9D9], Mouse Bispecific, anti-mPD-L1, Bispecific antibody, kappa (50 μg)

VECTOR LABS

Be the first to review this product

Quick Overview

The antibody was raised against CTLA-4.

$531.70

Order will ship within 1-3 business days

Description

Product Class: Purified
Clone ID: 9D9
Heavy Chain Modification: Bispecific antibody
Synonyms: CD152; CTLA4; Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Fo
Amount: 50 μg
Application Codes Clone: block; IF
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This is a bispecific anti-mouse antibody created by fusing anti-PDL-1 VHH domains to the C-terminus of the heavy chains of the anti-mouse CTLA-4 antibody clone 9D9 in a mouse IgG1 D265A format. The mouse IgG1 D265A format is an Fc-silenced format, reducin
Specificity Statement: The antibody is specific for CTLA-4.
Application Notes: The antibody has been used to block CTLA-4 and has been shown to enhance T-cell immunity against tumours (Quezada et al, 2006). 9D9 also has an anti-B16/BL6 melanoma effect in non-irradiated tumour-bearing recipients when given as combinatorial therapy with Gvax (Peggs et al, 2009). Selby et al. (PMID: 24777248) show how conversion of the original mouse IgG2b to a mouse IgG2a greatly increases anti-tumor activity of the 9D9 antibody in both MC38 (C57BL/6 mice) and CT26 (BALB/c mice) models. This mechanism both involves blockade of CTLA4 as well as depletion of tumor-infiltrating regulatory T-cells. Fc Silent antibodies were shown to have reduced anti-tumor activity as they did not deplete tumor infiltrating regulatory T-cells, however they lead to expansion of peripheral Tregs.

Product Class:	Purified
Clone ID:	9D9
Heavy Chain Modification:	Bispecific antibody
Synonyms:	CD152; CTLA4; Cytotoxic T-Lymphocyte Associated Protein 4; Insulin-Dependent Diabetes Mellitus 12; Celiac Disease 3; Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4; Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Fo
Amount:	50 μg
Application Codes Clone:	block; IF
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This is a bispecific anti-mouse antibody created by fusing anti-PDL-1 VHH domains to the C-terminus of the heavy chains of the anti-mouse CTLA-4 antibody clone 9D9 in a mouse IgG1 D265A format. The mouse IgG1 D265A format is an Fc-silenced format, reducin
Specificity Statement:	The antibody is specific for CTLA-4.
Application Notes:	The antibody has been used to block CTLA-4 and has been shown to enhance T-cell immunity against tumours (Quezada et al, 2006). 9D9 also has an anti-B16/BL6 melanoma effect in non-irradiated tumour-bearing recipients when given as combinatorial therapy with Gvax (Peggs et al, 2009). Selby et al. (PMID: 24777248) show how conversion of the original mouse IgG2b to a mouse IgG2a greatly increases anti-tumor activity of the 9D9 antibody in both MC38 (C57BL/6 mice) and CT26 (BALB/c mice) models. This mechanism both involves blockade of CTLA4 as well as depletion of tumor-infiltrating regulatory T-cells. Fc Silent antibodies were shown to have reduced anti-tumor activity as they did not deplete tumor infiltrating regulatory T-cells, however they lead to expansion of peripheral Tregs.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews