Mfg Part Number
Ab01046-3.3
Vector Labs Ab01046-3.3 Anti-MAC-1 [YBM15.1], Mouse IgG2b, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was derived from fusions between the 210 RC Y3/Ag 1.2.3 rat myeloma cell line and spleen cells from rats hyperimmunized with adult mouse bone marrow.
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| Product Class: | Purified |
|---|---|
| Clone ID: | YBM15.1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD11b; Integrin alpha-M; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; YBM 15.1.6; YBM15.1.6 |
| Amount: | 200 μg |
| Application Codes Clone: | IHC; FC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes murine integrine MAC-1 (Itgam/Cd11b). This integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. |
| Application Notes: | This antibody is recommended for the detection and analysis of MAC-1, the murine equivalent of CD11b. For instance, YBM15.1 was used in a panel of antibodies in the assessment of the presence of antigenic determinants on normal erythroid progenitors via flow cytometry (Watt et al., 1987; pmid: 3330997). This antibody was used to detect the integrin MAC-1 in the neural tissue of Biozzi ABH mice infected with Semliki Forest virus (SFV) A7(74) via immunohistochemistry (Smith et al., 2000; pmid: 10814783). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |