Vector Labs Ab01106-2.3 Anti-influenza [T1-3B], Mouse IgG2a, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: T1-3B
Heavy Chain Modification: Fc Silent™
Synonyms: Influenza H5; Influenza NP-A; Influenza A virus hemagglutinin glycoprotein; Influenza A virus HA; HA; hemagglutinin
Amount: 200 μg
Application Codes Clone: ELISA; IF; virus titration; hemagglutination inhibition test; microneutralization assays
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody reacts with the stem (VH 1-69*01) of H5 hemagglutinin glycoprotein (HA). Haemagglutinin is an antigenic glycoprotein which allows viral attachment and entry into the cell. Sixteen subtypes of haemagglutinin (H1-H16) have been described, of which H1, H2 and H3 infect humans. H5 and H7 normally result in avian disease, with some highly pathogenic H5N1 strains causing 100% mortality in poultry. H5N1 has in some cases mutated to infect humans, with 60% mortality. Haemagglutinin H5 is from the Influenza A virus H5N1. Influenza A belongs to the Orthomyxoviridae family, and is a negative sense single-stranded RNA virus which results in respiratory disease. Haemagglutinin is one of the most medically relevant antigens on influenza as it is a target for antiviral drugs and antibodies.
Application Notes: In the original study, this antibody was used in conjunction with other mAbs (e.g. N2B10 mAb specific for the head of seasonal H3 HA; T2-9A mAb specific for the head of H1N1pdm09) for enzyme-linked immunosorbent, indirect immunofluorescent, virus titration, hemagglutination inhibition (HAI), and microneutralization (MN) assays to show that assessing antigenic relatedness of evolving influenza viruses with panels of defined, renewable, and human monoclonal antibodies could be a very useful an adjunct to ferret antisera in detection of antigenic drift and in the selection of viruses for inclusion in influenza vaccines (Huang et al., 2015).

Product Class:	Purified
Clone ID:	T1-3B
Heavy Chain Modification:	Fc Silent™
Synonyms:	Influenza H5; Influenza NP-A; Influenza A virus hemagglutinin glycoprotein; Influenza A virus HA; HA; hemagglutinin
Amount:	200 μg
Application Codes Clone:	ELISA; IF; virus titration; hemagglutination inhibition test; microneutralization assays
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody reacts with the stem (VH 1-69*01) of H5 hemagglutinin glycoprotein (HA). Haemagglutinin is an antigenic glycoprotein which allows viral attachment and entry into the cell. Sixteen subtypes of haemagglutinin (H1-H16) have been described, of which H1, H2 and H3 infect humans. H5 and H7 normally result in avian disease, with some highly pathogenic H5N1 strains causing 100% mortality in poultry. H5N1 has in some cases mutated to infect humans, with 60% mortality. Haemagglutinin H5 is from the Influenza A virus H5N1. Influenza A belongs to the Orthomyxoviridae family, and is a negative sense single-stranded RNA virus which results in respiratory disease. Haemagglutinin is one of the most medically relevant antigens on influenza as it is a target for antiviral drugs and antibodies.
Application Notes:	In the original study, this antibody was used in conjunction with other mAbs (e.g. N2B10 mAb specific for the head of seasonal H3 HA; T2-9A mAb specific for the head of H1N1pdm09) for enzyme-linked immunosorbent, indirect immunofluorescent, virus titration, hemagglutination inhibition (HAI), and microneutralization (MN) assays to show that assessing antigenic relatedness of evolving influenza viruses with panels of defined, renewable, and human monoclonal antibodies could be a very useful an adjunct to ferret antisera in detection of antigenic drift and in the selection of viruses for inclusion in influenza vaccines (Huang et al., 2015).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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