Mfg Part Number
Ab01121-2.0
Vector Labs Ab01121-2.0 Anti-CD21 [THB-5], Mouse IgG2a, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with human B cells of the SB line. Spleen cells were then removed and fused with Ag8.653 myeloma cells, to produce stable hybridomas.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | THB-5 |
| Synonyms: | CR2; Complement receptor type 2; ; complement C3d receptor;C3dR; C3DR; Epstein-Barr virus receptor; EBV receptor; cluster of differentiation 21; THB 5 |
| Amount: | 200 μg |
| Application Codes Clone: | IF; FC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 19889766 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for human CD21 (complement receptor type 2), which is expressed on B-cells and participates in B cell activation. It recognises a distinct antigenic site to the anti-B2 antibody (Tedder et al, 1984). |
| Application Notes: | The binding specificity of this antibody has been confirmed in flow cytometry and immunofluorescence analysis (Tedder et al, 1984), with only B cell reactivity observed. Though this antibody binds to CD21, which acts as a receptor for Epstein-Barr virus (EBV), it cannot alone block viral entry into B cells (Fingeroth et al, 1984). EBV virions engineered to express this antibody at their surface have been used to probe the need for CD21 binding to achieve viral entry (Busse et al, 2010). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |