Mfg Part Number
Ab01122-13.12
Vector Labs Ab01122-13.12 Anti-CD81 [CD81K04], Human IgG4-S228P, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c and Naval Medical Research Institute (NMRI) mice with CD81 extracellular loop 2 (ECL2) protein or with CHO‐CD81 cells.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | CD81K04 |
| Synonyms: | TSPAN-28; K04; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28 |
| Amount: | 200 μg |
| Application Codes Clone: | crystallisation; neutralisation; FC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 26637054 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for a conformational epitope in the extracellular domain of human CD81, a receptor used by hepatitis C virus to infect human hepatocytes. |
| Application Notes: | This antibody has been identified as a potential anti-hepatitis C virus (HCV) agent (Ji et al, 2015). It displays potent and broad-spectrum inhibition of HCV entry in vitro, and has been shown to both prevent HCV infection and limit HCV spread in mice models (Ji et al, 2015) by blocking viral engagement of CD81.The binding specificity of this antibody has been confirmed in FACS analysis (Ji et al, 2015). A Fab fragment of this antibody has been used to determine the crystal structure of CD81K04 binding to the large extracellular loop of CD81 (Bujotzek et al, 2016). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |