Mfg Part Number
Ab01124-23.0
Vector Labs Ab01124-23.0 Anti-CCR5 [ST6], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was isolated from a phage displayed antibody fragment library. The library was generated from a New Zealand White rabbit immunised with purified CCR5-N-GST protein, and four rounds of panning were completed against immobilised CCR5-N-MBP antigen.
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| Product Class: | Purified |
|---|---|
| Clone ID: | ST6 |
| Synonyms: | CD195; C-C chemokine receptor type 5; C-C CKR-5; CC-CKR-5; CCR-5; CHEMR13; HIV-1 fusion coreceptor; B8LFP0 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; ELISA; SPR; depleting |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 10969070 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for the YTSE region of the N-terminal extracellular domain of human CCR5.It also binds to rhesus CCR5. |
| Application Notes: | When expressed intracellularly, this antibody is able to inhibit the surface expression of human CCR5, conferring T-lymphocytes with immunity to CCR5-dependent HIV-1 infection (Steinberger et al, 2000). Humanised ST6 (ST6/34) also has the same depleting effect (Steinberger et al, 2000). The high affinity of this antibody for CCR5-N-MBP has been confirmed in surface plasmon resonance analysis (Steinberg et al, 2000). This antibody has been used to stain CCR5-expressing cells in flow cytometry, with no staining of control cells observed (Steinberger et al, 2000). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |