Mfg Part Number
Ab01139-10.0
Vector Labs Ab01139-10.0 Anti-CD20 [B9E9], Human IgG1, kappa (200 μg)
Quick Overview
This antibody was raised against human CD20.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | B9E9 |
| Synonyms: | MS4A1; B-lymphocyte antigen CD20;MS4A1; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; E9PPL6; P19437 |
| Amount: | 200 μg |
| Application Codes Clone: | WB; radioimmunotherapy |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 11118050 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for CD20, which is expressed by normal and malignant B cells. It does not cross-react with murine CD20. |
| Application Notes: | This antibody has been used in western blot detection of CD20 in human plasma, revealing elevated CD20 levels in plasma from chronic lymphocytic leukemia patients (Manshouri et al, 2003). An scFv derived from this antibody fused to streptavidin has been investigated as a method of pretargeted radioimmunotherapy for lymphomas (Schultz et al, 2000), and has been demonstrated to be non-toxic in a phase I trial of non-Hodgkin lymphoma patients (Forero et al, 2004). Additionally, measles viruses engineered to express this scFv are able to enter CD20+ target cells through interaction with CD20 antigen, with clinical relevance for lymphoma therapy (Bucheit et al, 2003). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |