Mfg Part Number
Ab01142-10.3
Vector Labs Ab01142-10.3 Anti-HLA allele DQB1*0601 [LG11], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with unconjugated free synthetic DQB1 peptides (region 70–90).
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | LG11 |
| Heavy Chain Modification: | Fc Silent™ |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; blocking |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 29034433 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognises peptides corresponding to the tip of the MHC antigen-binding cavity (region 70 - 90) of HLA allele DQB1*0601 (RTRAELDTVCRHNYEVAFRGI). It cross-reacts with peptide DQB1*03/70–90, and the shorter peptide DQB1*06/70–79 |
| Application Notes: | This antibody blocks the myasthenia gravis (MG)-associated DQ beta 1 allele, and is able to inhibit the proliferation of T cells from MG patients (Ayyar & Atassi, 2017). A humanised scFv derived from this antibody, which has been confirmed in ELISA analysis to recognise the same epitope, is also able to block the proliferation of T cells from MG patients typed DQB1*0601 (Ayyar & Atassi, 2017). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |