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Mfg Part Number

Ab01146-1.1

Vector Labs Ab01146-1.1 Anti-Neisseria meningitidis group B capsular polysaccharide [HmenB3], Mouse IgG1, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising BALB/cByJ mice with E. coli K1 bacteria (strain RS218). The E. coli K1 capsular polysaccharide antigen shows structural and immunological identity with the meningococcal group B antigen, as both are α(2-8)-linked p

$517.40

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Description

Product Class: Purified
Clone ID: HmenB3
Synonyms: CPS 6B; capsular PS B
Amount: 200 μg
Application Codes Clone: FC; ELISA; bactericidal
Shipping Temperature: Wet Ice
Origin Pub PMID: 12055241
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgM
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds to the capsular polysaccharide of both Neisseria meningitidis group B and E. coli K1. It also reacts with EV36, a nonpathogenic E. coli K-12 strain
Application Notes: The binding characteristics of this antibody have been assessed in flow cytometric analysis; this antibody binds to N. meningitidis group B and E. coli EV36 (Shin et al, 2001). It does not react with N. meningitidis groups A, C, and Y, and is non-autoreactive, as it does not react with human neuronal α(2-8) polysialic acid (Shin et al, 2001). This antibody has been used in a sandwich type ELISA to investigate the cross-reactivity of bacteriophage clones displaying the antigenic properties of serotype 6B pneumococcal capsular polysaccharide (Shin et al, 2002). In the presence of rabbit and human complement, this antibody exhibits bactericidal activity (Shin et al, 2001).

Product Class:	Purified
Clone ID:	HmenB3
Synonyms:	CPS 6B; capsular PS B
Amount:	200 μg
Application Codes Clone:	FC; ELISA; bactericidal
Shipping Temperature:	Wet Ice
Origin Pub PMID:	12055241
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgM
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds to the capsular polysaccharide of both Neisseria meningitidis group B and E. coli K1. It also reacts with EV36, a nonpathogenic E. coli K-12 strain
Application Notes:	The binding characteristics of this antibody have been assessed in flow cytometric analysis; this antibody binds to N. meningitidis group B and E. coli EV36 (Shin et al, 2001). It does not react with N. meningitidis groups A, C, and Y, and is non-autoreactive, as it does not react with human neuronal α(2-8) polysialic acid (Shin et al, 2001). This antibody has been used in a sandwich type ELISA to investigate the cross-reactivity of bacteriophage clones displaying the antigenic properties of serotype 6B pneumococcal capsular polysaccharide (Shin et al, 2002). In the presence of rabbit and human complement, this antibody exhibits bactericidal activity (Shin et al, 2001).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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