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Mfg Part Number

Ab01166-23.0

Vector Labs Ab01166-23.0 Anti-polymorphic epithelial mucin [CTM01], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising mice with human milk fat globule membrane

$517.40

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Description

Product Class: Purified
Clone ID: CTM01
Synonyms: MUC1; 7F11C7; PEM; CT-M-01; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial
Amount: 200 μg
Application Codes Clone: IP; IHC; therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG21
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG21 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the glycoprotein polymorphic epithelial mucin (MUC1), expression of which is elevated in a broad range of solid tumours of epithelial origin.
Application Notes: The binding specificity of this antibody for HMFGM has been confirmed in ELISA analysis (Aboud-Pirak et al, 1988). Once bound to its antigen on the plasma membrane of human breast carcinoma MCF-7, this antibody is rapidly endocytosed and delivered to lysosomes for digestion, as established in radiolabelling and fractionation studies (Aboud-Pirak et al, 1988). An 111lndium-labeled human-engineered form of this antibody has been shown to be a suitable carrier for cytotoxic agents in ovarian carcinoma patients (van Hof et al, 1996). Equally, when conjugated to calicheamicin amide, this antibody can target the antitumor antibiotic into MUC1-positive solid tumors (Hamann et al, 2005).

Product Class:	Purified
Clone ID:	CTM01
Synonyms:	MUC1; 7F11C7; PEM; CT-M-01; Mucin-1; MUC-1; Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial
Amount:	200 μg
Application Codes Clone:	IP; IHC; therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG21
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG21 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the glycoprotein polymorphic epithelial mucin (MUC1), expression of which is elevated in a broad range of solid tumours of epithelial origin.
Application Notes:	The binding specificity of this antibody for HMFGM has been confirmed in ELISA analysis (Aboud-Pirak et al, 1988). Once bound to its antigen on the plasma membrane of human breast carcinoma MCF-7, this antibody is rapidly endocytosed and delivered to lysosomes for digestion, as established in radiolabelling and fractionation studies (Aboud-Pirak et al, 1988). An 111lndium-labeled human-engineered form of this antibody has been shown to be a suitable carrier for cytotoxic agents in ovarian carcinoma patients (van Hof et al, 1996). Equally, when conjugated to calicheamicin amide, this antibody can target the antitumor antibiotic into MUC1-positive solid tumors (Hamann et al, 2005).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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