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Mfg Part Number

Ab01167-10.3

Vector Labs Ab01167-10.3 Anti-osteosarcoma-associated cell membrane antigen [TP-3], Human IgG1, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising BALB/c mice with tumor cells from a human osteosarcoma, TPX, grown as a xenograft in athymic BALB/c nude mice.

$517.40

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Description

Product Class: Purified
Clone ID: TP-3
Heavy Chain Modification: Fc Silent™
Amount: 200 μg
Application Codes Clone: IHC; IF; radioimmunodetection
Shipping Temperature: Wet Ice
Origin Pub PMID: 8679259
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This osteosarcoma-specific antibody binds an epitope on an alkaline phosphatase isoform expressed on both canine and human osteosarcoma cells, but with very limited expression on normal cells and other cancer forms. It also reacts with some other major subtypes of human sarcomas.
Application Notes: In indirect immunofluorescence assays, this antibody has been show to bind to the surface of human osteosarcoma TPX cells, but not to autologous skin fibroblasts, non-sarcomatous tumor cells or peripheral blood lymphocytes (Bruland et al, 1986).In IHC analysis, this antibody has been shown to bind to osteosarcomas, along with other major human sarcoma subtypes, including synovial sarcomas, malignant fibrous histiocytomas, malignant hemangiopericytomas and chondrosarcomas. It does not react with liposarcomas and leio- and rhabdomyosarcomas, or non-sarcomatous malignancies or normal tissue (Bruland et al, 1986). This binding profile matches that of MAb TP-1. A radiolabelled version of this antibody localises to human osteogenic sarcoma xenografts after intravenous injection (Bruland et al, 1987).

Product Class:	Purified
Clone ID:	TP-3
Heavy Chain Modification:	Fc Silent™
Amount:	200 μg
Application Codes Clone:	IHC; IF; radioimmunodetection
Shipping Temperature:	Wet Ice
Origin Pub PMID:	8679259
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This osteosarcoma-specific antibody binds an epitope on an alkaline phosphatase isoform expressed on both canine and human osteosarcoma cells, but with very limited expression on normal cells and other cancer forms. It also reacts with some other major subtypes of human sarcomas.
Application Notes:	In indirect immunofluorescence assays, this antibody has been show to bind to the surface of human osteosarcoma TPX cells, but not to autologous skin fibroblasts, non-sarcomatous tumor cells or peripheral blood lymphocytes (Bruland et al, 1986).In IHC analysis, this antibody has been shown to bind to osteosarcomas, along with other major human sarcoma subtypes, including synovial sarcomas, malignant fibrous histiocytomas, malignant hemangiopericytomas and chondrosarcomas. It does not react with liposarcomas and leio- and rhabdomyosarcomas, or non-sarcomatous malignancies or normal tissue (Bruland et al, 1986). This binding profile matches that of MAb TP-1. A radiolabelled version of this antibody localises to human osteogenic sarcoma xenografts after intravenous injection (Bruland et al, 1987).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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