Mfg Part Number
Ab01189-23.0
Vector Labs Ab01189-23.0 Anti-Thyroid peroxidase [WR1.7], Rabbit IgG, kappa (200 μg)
Quick Overview
A cDNA library was constructed from the thyroid tissue of patients with Grave's disease, and antibody fragments were expressed in XL1-Blue cells.
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| Product Class: | Purified |
|---|---|
| Clone ID: | WR1.7 |
| Synonyms: | TPO |
| Amount: | 200 μg |
| Application Codes Clone: | RIA; competition assays; FC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 7686925 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody specifically targets human TPO, a cell surface enzyme critical for thyroid hormone synthesis. TPO is found in nearly all patients with active autoimmune thyroid disease. |
| Application Notes: | The original form of this antibody (human IgG1) binds human TPO with a Kd of 0.29 nM (Chazenbalk et al., 1993; PMID: 7686925). Competition assays revealed that this antibody binds a distinct epitope compared to clone TR1.9 (Chazenbalk et al., 1993; PMID: 7686925). Further competition studies demonstrated that this antibody inhibits TPO autoantibodies in patients' sera by interacting with serum TPO autoantibodies (Chazenbalk et al., 1993; PMID: 7505290). Alongside clones TR1.9, SP1.4, and TR1.8, this antibody maps to the immunodominant region of TPO recognized by autoantibodies in patient sera (Nishikawa et al., 1994; PMID: 7512572). This antibody has also been employed in flow cytometry to detect cells expressing surface TPO (Jaume et al., 1999; PMID: 10323395). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |