Mfg Part Number
Ab01202-23.0
Vector Labs Ab01202-23.0 Anti-gp120 [u5.5], Rabbit IgG, kappa (200 μg)
Quick Overview
Mice were immunised with HTLV-IIIMN cells. Spleen cells were harvested and hybridomas generated.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | u5.5 |
| Synonyms: | Ru5.5; gp120; Envelope glycoprotein gp160; Env polyprotein; transmembrane protein gp41; TM gp41; glycoprotein 41; gp41; surface protein gp120; SU gp120; mu5.5 |
| Amount: | 200 μg |
| Application Codes Clone: | Neutralisation; ELISA; WB |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 9551957 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | Specific to the principal neutralizing determinant (PND) of the V3 region of gp120 of HIV-1. It is reactive against peptides longer than 11 mer containing the sequence IHIGPGRAFYT (Okamoto et al, 1998). |
| Application Notes: | Has been tested against the primary field isolates of Japanese hemophiliacs seropositive for HIV-1 and protect SCID-hu mice from infection from these isolates. u5.5 was used as a humanized antibody and found to have a high neutralization activity. As of such it has been proposed as a protective antibody, however its epitope specificity gives it a limited range (Okamoto et al, 1998). It has been used in Western Blots to detect the V3 epitope of HIV-1 (Honda et al, 1995). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |