Mfg Part Number
Ab01225-23.0
Vector Labs Ab01225-23.0 Anti-GPIIB/IIIA [PDG7], Rabbit IgG, lambda (200 μg)
Quick Overview
A phagemid library was constructed from the peripheral blood lymphocytes of a donor who was immunised with RhD+ red blood cells, and PDG7 was isolated after five rounds of affinity selection.
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| Product Class: | Purified |
|---|---|
| Clone ID: | PDG7 |
| Synonyms: | glycoprotein IIb/IIIa; integrin αIIbβ3; |
| Amount: | 200 μg |
| Application Codes Clone: | inhibition assays; dot blot |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 9722313 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | Fab |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human Fab format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | PDG7 does not bind to antigen denatured by heat of pH, indicating the necessity of intact GPIIb/IIIa. |
| Application Notes: | Dot blots confirmed the specificity of PDG7 for GPIIB/IIIA. Inhibition assays were used to show that platelet-associated autoantibodies from AITP patients binds a closely related epitope to that of the recombinant anti-GPIIb/IIIa phage clones (Escher et al, 1998). Inhibition studies also confirmed that PDG7 inhibited binding of eluted platelet-associated autoantibodies from AITP patients to platelets (Escher et al, 1998). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |