Mfg Part Number
Ab01237-1.9
Vector Labs Ab01237-1.9 Anti-Marburg virus nucleoprotein [sdAb 4], Mouse IgG1-Fc fusion, His-tagged, (200 μg)
Quick Overview
An unbiased phage display library was generated by extracting RNA from llama blood samples. Phage-display with the MARV-Mus strain was used to select sdAb B from the phage library.
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| Product Class: | Purified |
|---|---|
| Clone ID: | sdAb 4 |
| Heavy Chain Modification: | His-tagged |
| Synonyms: | Marburg virus NP |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; crystallography; cross-linking |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 29038656 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | sdAb |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using a variable domain sequence of the original VHH format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | sdAb B is specific for MARV-Mus, -Rav, and -Ang strains of the MARV virus but shows no cross-reactivity with representative strains of the 4 EBOV species. The antibody recognises NP, a critical viral structural protein that envelopes the RNA genome. |
| Application Notes: | ELISA was used to establish the specificity of sdAb B for MARV virus strains (Sherwood et al, 2007). sdAb has been crystallised with its antigen NP (Garza et al, 2017). Cross-linking dimeric sdAb to NP restricted viral packaging (Darling et al, 2017). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |