Mfg Part Number
Ab01259-8.1
Vector Labs Ab01259-8.1 Anti-IL-6R [D7715A7], Rat IgG2b, kappa (200 μg)
Quick Overview
This antibody was raised by immunising Lewis rats with OKT4 cells.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | D7715A7 |
| Synonyms: | CD126; 15A7; IL-6Ra; IL6R; Interleukin-6 receptor subunit alpha; Il6ra; IL-6 receptor subunit alpha; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1 |
| Amount: | 200 μg |
| Application Codes Clone: | blocking; FC; therapeutic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2b |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for murine IL-6R. |
| Application Notes: | This antibody binds to IL-6R-positive cells, and blocks IL-6 binding (Vink et al, 1990; Coulie et al, 1990). This antibody is able to inhibit the growth of IL6-dependent plasmacytoma T1033C2 in vitro (Coulie et al, 1990). Administration of this antibody to mice prior to challenge with T1033C2 resulted in a protection rate of 60% and prolonged survival in tumour-bearing mice (Vink et al, 1990). This antibody has been used in flow cytometry to assess IL-6Ra expression (Hoge et al, 2013). When added to dendritic cells subject to CD40 activation in vitro, this antibody neutralises IL-6 and ablates the effect of CD40 activation (Grohmann et al, 2001). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |