Mfg Part Number
Ab01266-23.0
Vector Labs Ab01266-23.0 Anti-IL-17A [MM17F3], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was raised by immunising C57Bl/6 mice with IL-17A cross-linked to ovalbumin to generate a highly immunogenic complex.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | MM17F3 |
| Synonyms: | Interleukin-17A; IL17A; Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; blocking; therapeutic |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is highly specific for murine IL-17A; in ELISA analysis, no cross-reactivity with IL‐17B, IL‐17C, IL‐17D, IL‐17E or IL‐17F was observed. |
| Application Notes: | The specificity of this antibody has been confirmed in ELISA analysis (Uyttenhove et al, 2006). This antibody inhibits IL‐17A‐induced IL‐6 production by a Cl1D fibroblastic cell line in vitro (Uyttenhove et al, 2006). This antibody has been shown to prevent experimental autoimmune encephalomyelitis (EAE) disease development in vivo (Uyttenhove et al, 2006), as well as protecting C57Bl/6 mice from myelin oligdendrocyte glycoprotein (MOG)-induced EAE (Uyttenhove et al, 2007). Additionally, administration of this antibody inhibits collagen-induced arthritis (CIA) in IFN-γ receptor knockout mice (Kelchtermans et al, 2009). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |