Mfg Part Number
Ab01276-10.3
Vector Labs Ab01276-10.3 Anti-hINSR [IR 18-40], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with purified human placental insulin receptor.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | IR 18-40 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD220; human insulin receptor; insulin receptor; HHF5; IR; 18 40 |
| Amount: | 200 μg |
| Application Codes Clone: | IP; IB |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody reacts with the extracellular domain of human INSR, and recognises an epitope on the beta subunit. It does not cross-react with rat or mouse insulin receptors, and cross-reacts weakly with rabbit, bovine, porcine and ovine INSR. |
| Application Notes: | This antibody has been used in immunoprecipitation assays, with both radiolabelled human insulin receptor (hINSR) and hINSR-radiolabelled insulin complexes (Soos et al, 1986). This antibody has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986), revealing that it reacts with the receptor's beta subunit. This antibody has been shown to have limited inhibitory effect on insulin binding to IM-9 cells (Soos et al, 1986). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |