Mfg Part Number
Ab01279-1.1
Vector Labs Ab01279-1.1 Anti-hINSR [IR 47-46], Mouse IgG1, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/c mice with IM-9 lymphocytes, and boosting with purified human placental insulin receptor prior to fusion.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | IR 47-46 |
| Synonyms: | CD220; human insulin receptor; insulin receptor; HHF5; IR; 47 46 |
| Amount: | 200 μg |
| Application Codes Clone: | IP; IB; blocking |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody reacts with human INSR, recognising an epitope on the alpha subunit (amino acids 485-592). It does not cross-react with rat or mouse insulin receptors, and does cross-react with bovine and rabbit receptors. |
| Application Notes: | This antibody has been used in immunoprecipitation assays with radiolabelled human insulin receptor (hINSR) (Soos et al, 1986). It has also been used in immunoblot analysis with purified hINSR (Soos et al, 1986), revealing that it binds to the receptor’s alpha subunit. This antibody has been shown to cause >80% inhibition of insulin binding to IM-9 cells (Soos et al, 1986), and to block receptor activation. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |