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Mfg Part Number

Ab01284-3.3

Vector Labs Ab01284-3.3 Anti-IGF1R [IGFR 16-13], Mouse IgG2b, Fc Silent™, lambda (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising BALB/c mice with transfected mouse fibroblasts expressing high levels of human IGF1R (IGF1R/3T3).

$517.40

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Description

Product Class: Purified
Clone ID: IGFR 16-13
Heavy Chain Modification: Fc Silent™
Synonyms: CD221; IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; 6 13
Amount: 200 μg
Application Codes Clone: IP; stimulatory
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement: This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically a conformation-dependent epitope in the alpha subunit (amino acids 62-184). It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays.
Application Notes: The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates IGF1R solubilized from IGF1R/3T3 cells and receptor-IGF1 complexes (Soos et al, 1992). When immobilised, this antibody has been shown to remove 90% of all soluble IGF1R in immunodepletion experiments (Soos et al, 1992). It has also been used to capture IGF1R N-terminal fragments as part of a ligand plate binding assay (Molina et al, 2000). This antibody strongly stimulates both IGF1 and insulin binding to IGF1R/3T3 cells, and potentiates insulin stimulation of DNA synthesis (Soos et al, 1992).

Product Class:	Purified
Clone ID:	IGFR 16-13
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD221; IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; 6 13
Amount:	200 μg
Application Codes Clone:	IP; stimulatory
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Specificity Statement:	This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically a conformation-dependent epitope in the alpha subunit (amino acids 62-184). It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays.
Application Notes:	The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates IGF1R solubilized from IGF1R/3T3 cells and receptor-IGF1 complexes (Soos et al, 1992). When immobilised, this antibody has been shown to remove 90% of all soluble IGF1R in immunodepletion experiments (Soos et al, 1992). It has also been used to capture IGF1R N-terminal fragments as part of a ligand plate binding assay (Molina et al, 2000). This antibody strongly stimulates both IGF1 and insulin binding to IGF1R/3T3 cells, and potentiates insulin stimulation of DNA synthesis (Soos et al, 1992).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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