Vector Labs Ab01285-23.0 Anti-IGF1R [IGFR 17-69], Rabbit IgG, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: IGFR 17-69
Synonyms: CD221; IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; 17 69
Amount: 200 μg
Application Codes Clone: IP; blocking
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically an epitope in the alpha subunit (amino acids 514-586). It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays, but does react with both rabbit and pig IGFR.
Application Notes: The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates human IGF1R (Soos et al, 1992), and has been used in immunoprecipitation analysis of 293 cells transfected with hIGF1R or chimeric hIGF1R-insulin receptor constructs (Schumacher et al, 1993) and solubilized microsomal membrane samples prepared from a range of human tissues (Bailyes et al, 1997). Given its reactivity with rabbit IGF1R, this antibody has also been used in immunoprecipitation analysis of rabbit tissue samples (Bailyes et al, 1997). When immobilised, this antibody has been shown to remove essentially all soluble, IGF1R/3T3-derived IGF1R (Soos et al, 1992) and human placental membrane-derived IGF1R in immunodepletion experiments (Soos et al, 1993). This antibody weakly inhibits IGF1 binding to its receptor (Soos et al, 1993).

Product Class:	Purified
Clone ID:	IGFR 17-69
Synonyms:	CD221; IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; 17 69
Amount:	200 μg
Application Codes Clone:	IP; blocking
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically an epitope in the alpha subunit (amino acids 514-586). It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays, but does react with both rabbit and pig IGFR.
Application Notes:	The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates human IGF1R (Soos et al, 1992), and has been used in immunoprecipitation analysis of 293 cells transfected with hIGF1R or chimeric hIGF1R-insulin receptor constructs (Schumacher et al, 1993) and solubilized microsomal membrane samples prepared from a range of human tissues (Bailyes et al, 1997). Given its reactivity with rabbit IGF1R, this antibody has also been used in immunoprecipitation analysis of rabbit tissue samples (Bailyes et al, 1997). When immobilised, this antibody has been shown to remove essentially all soluble, IGF1R/3T3-derived IGF1R (Soos et al, 1992) and human placental membrane-derived IGF1R in immunodepletion experiments (Soos et al, 1993). This antibody weakly inhibits IGF1 binding to its receptor (Soos et al, 1993).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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