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Mfg Part Number

Ab01291-10.3

Vector Labs Ab01291-10.3 Anti-IGF1R [IGFR 26-3], Human IgG1, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising BALB/c mice with transfected mouse fibroblasts expressing high levels of human IGF1R (IGF1R/3T3).

$517.40

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Description

Product Class: Purified
Clone ID: IGFR 26-3
Heavy Chain Modification: Fc Silent™
Synonyms: CD221; IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; 26 3
Amount: 200 μg
Application Codes Clone: IP; stimulatory
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically an epitope in the alpha subunit (amino acids 283-440). It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays.
Application Notes: The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates IGF1R solubilized from IGF1R/3T3 cells and receptor-IGF1 complexes (Soos et al, 1992). When immobilised, this antibody has been shown to remove essentially all soluble IGF1R in immunodepletion experiments (Soos et al, 1992). This antibody strongly stimulates both IGF1 and insulin binding to IGF1R/3T3 cells, and potentiates insulin stimulation of DNA synthesis (Soos et al, 1992; Siddle et al, 1994).

Product Class:	Purified
Clone ID:	IGFR 26-3
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD221; IGF1 receptor; Insulin-like growth factor 1 receptor; type I IGF receptor; Insulin-like growth factor I receptor; IGF-I receptor; 26 3
Amount:	200 μg
Application Codes Clone:	IP; stimulatory
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for the human insulin-like growth factor 1 receptor (IGF1R). It recognises the extracellular portion of the receptor, specifically an epitope in the alpha subunit (amino acids 283-440). It does not cross-react with rat or mouse IGF1R or human insulin receptors in co-precipitation or immunodepletion assays.
Application Notes:	The ability of this antibody to bind human IGF1R has been confirmed in IGF1 binding assays using both IG1FR-overexpressing IGF1R/3T3 cells and soluble receptors (Soos et al, 1992). This antibody efficiently precipitates IGF1R solubilized from IGF1R/3T3 cells and receptor-IGF1 complexes (Soos et al, 1992). When immobilised, this antibody has been shown to remove essentially all soluble IGF1R in immunodepletion experiments (Soos et al, 1992). This antibody strongly stimulates both IGF1 and insulin binding to IGF1R/3T3 cells, and potentiates insulin stimulation of DNA synthesis (Soos et al, 1992; Siddle et al, 1994).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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