JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.

Skip to the beginning of the images gallery

Mfg Part Number

Ab01295-2.3-VXL

Vector Labs Ab01295-2.3-VXL Anti-LAG-3 [C9B7W], Mouse IgG2a, Fc Silent™, kappa (10 mg)

VECTOR LABS

Be the first to review this product

Quick Overview

This antibody was raised by immunising Lewis rats with a murine LAG-3:Ig fusion protein.

$2,013.70

Order will ship within 1-3 business days

Description

Product Class: VivopureX
Clone ID: C9B7W
Heavy Chain Modification: Fc Silent™
Synonyms: CD223; LAG3; Lymphocyte activation gene 3 protein
Amount: 10 mg
Application Codes Clone: FC; IP; blocking
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: IgG1
Storage Temperature: All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for an epitope in the D2 domain of murine LAG-3.
Application Notes: This antibody has been used in flow cytometric analysis of splenocytes (Workman et al, 2005), T cell hybridomas expressing wild‐type or chimeric CD4:murine LAG-3 (Workman et al, 2002) and CD4+ regulatory T cells (Chien et al, 2017). It has also been used in immunoprecipitation analysis of murine T hybridoma 3A9 cells transduced with murine LAG-3 (Li et al, 2004). This antibody blocks LAG-3 function in vitro, inhibiting antigen‐induced IL‐2 production in LAG-3-expressing T cell hybridomas, but does not block LAG-3:MHC class II interaction (Workman et al, 2002). Treatment with this antibody also blocks LAG-3 function in vivo, leading to accelerated homeostatic expansion of WT T cells (Workman et al, 2005). Administration of this LAG-3-blocking antibody, in combination with PD-L1 blockade, synergistically improves the survival of lymphodepleted myeloma-bearing mice (Jing et al, 2015).

Product Class:	VivopureX
Clone ID:	C9B7W
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD223; LAG3; Lymphocyte activation gene 3 protein
Amount:	10 mg
Application Codes Clone:	FC; IP; blocking
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	IgG1
Storage Temperature:	All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for an epitope in the D2 domain of murine LAG-3.
Application Notes:	This antibody has been used in flow cytometric analysis of splenocytes (Workman et al, 2005), T cell hybridomas expressing wild‐type or chimeric CD4:murine LAG-3 (Workman et al, 2002) and CD4+ regulatory T cells (Chien et al, 2017). It has also been used in immunoprecipitation analysis of murine T hybridoma 3A9 cells transduced with murine LAG-3 (Li et al, 2004). This antibody blocks LAG-3 function in vitro, inhibiting antigen‐induced IL‐2 production in LAG-3-expressing T cell hybridomas, but does not block LAG-3:MHC class II interaction (Workman et al, 2002). Treatment with this antibody also blocks LAG-3 function in vivo, leading to accelerated homeostatic expansion of WT T cells (Workman et al, 2005). Administration of this LAG-3-blocking antibody, in combination with PD-L1 blockade, synergistically improves the survival of lymphodepleted myeloma-bearing mice (Jing et al, 2015).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews