Vector Labs Ab01301-1.6-BS Anti-EME1 [7h2/1], Mouse Fab fragment, His-Tagged, kappa (1 mg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 7h2/1
Heavy Chain Modification: His-Tagged
Synonyms: Essential meiotic endonuclease 1; Crossover junction endonuclease EME1; MMS4 homolog; hMMS4; EC 3.1.22; EC 3.1.22.; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic endonuclease 1 homolog 2; FLJ31364; homolog of yeast EME1 endonuclease; MMS4L; MMS4; SLX2 structure-specific endonuclease subunit homolog A; SLX2A; MTA31
Amount: 1 mg
Application Codes Clone: WB; IP; IF; IHC
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognises human EME1. EME1 together with MUS81 create a DNA endonuclease which binds preferentially to branched DNA structures such as Holliday junctions and replication forks. It's engaged in processing of stalled or collapsed replication forks in mitosis.
Application Notes: WB: MTA31 7h2/1 antibody was used to detect EME1 in western blot analysis in the experiments assessing EME1 as a potential marker of cisplatin resistance in cancer therapy (Tomoda et al., 2009). WB: This antibody was used to detect EME1 on western blots after previous immunopurification procedure (Laguette et al., 2014). IHC: Other group conducted an immunohistochemistry experiment staining against EME1 in formalin-fixed paraffin embedded esophageal adenocarcinoma tissue samples using MTA31 7h2/1 antibody (Dwalt et al., 2014).

Product Class:	Purified
Clone ID:	7h2/1
Heavy Chain Modification:	His-Tagged
Synonyms:	Essential meiotic endonuclease 1; Crossover junction endonuclease EME1; MMS4 homolog; hMMS4; EC 3.1.22; EC 3.1.22.; essential meiotic endonuclease 1 homolog 1 (S. pombe); essential meiotic endonuclease 1 homolog 2; FLJ31364; homolog of yeast EME1 endonuclease; MMS4L; MMS4; SLX2 structure-specific endonuclease subunit homolog A; SLX2A; MTA31
Amount:	1 mg
Application Codes Clone:	WB; IP; IF; IHC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognises human EME1. EME1 together with MUS81 create a DNA endonuclease which binds preferentially to branched DNA structures such as Holliday junctions and replication forks. It's engaged in processing of stalled or collapsed replication forks in mitosis.
Application Notes:	WB: MTA31 7h2/1 antibody was used to detect EME1 in western blot analysis in the experiments assessing EME1 as a potential marker of cisplatin resistance in cancer therapy (Tomoda et al., 2009). WB: This antibody was used to detect EME1 on western blots after previous immunopurification procedure (Laguette et al., 2014). IHC: Other group conducted an immunohistochemistry experiment staining against EME1 in formalin-fixed paraffin embedded esophageal adenocarcinoma tissue samples using MTA31 7h2/1 antibody (Dwalt et al., 2014).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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