Mfg Part Number
Ab01322-1.1
Vector Labs Ab01322-1.1 Anti-BLC2 [bcl-2/124], Mouse IgG1, kappa (200 μg)
Quick Overview
This antibody was raised against a synthetic peptide of amino acids 41-54 of human bcl-2 oncoprotein.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | bcl-2/124 |
| Synonyms: | Apoptosis regulator Bcl-2; AW986256; B-cell CLL/lymphoma 2; Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik; protein phosphatase 1; regulatory subunit 50; bcl-2-124; bcl2/124 |
| Amount: | 200 μg |
| Application Codes Clone: | IHC; WB; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody recognises human BLC-2 which is an antiapoptotic factor in various cell types. Its disregulation was implicated in different conditions, such as cancers and autoimmune disorders. |
| Application Notes: | This antibody has been used extensively in attempts aimed at characterising various cancer tissues via immunohistochemical staining. One group used bcl-2-124 antibody to label large B-cell lymphoma samples for bcl2 in order to perform its immunophenotypic and genetic depiction (Chang et al., 2016). Another group took advantage of this antibody while analysing the molecular picture of a case of the cystic synovial sarcoma of the pleura where they observed positive immunohistochemical staining in tumor cells (Tajima et al., 2015). Bcl-2 plays an important role as an inhibitor of apoptosis and its identification is often useful while analysing various factors influencing apoptosis. For instance, bcl-2/124 antibody has been successfully utilised in such experiments identifying bcl-2 via Western blot - Gomez-Bougie (2007) probed the influence of bortezomib on HMCL cells and detected bcl-2 signal on Western blots. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |