Mfg Part Number
Ab01323-1.1
Vector Labs Ab01323-1.1 Anti-Nucleophosmin [NA24], Mouse IgG1, kappa (200 μg)
Quick Overview
This antibody was raised by immunising BALB/C mice with GST fusion protein containing the N-terminal part of nucleophosmin fused to 14 amino acid of ALK protein.
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| Product Class: | Purified |
|---|---|
| Clone ID: | NA24 |
| Synonyms: | NPM; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; B23; NPM1; Nucleolar protein NO38 |
| Amount: | 200 μg |
| Application Codes Clone: | IHC; WB; IF; IP |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific towards nucleophasmin which is a widely expressed phosphorylated protein involved in various processes, such as ribosome assebly and transport, cell proliferation, protein chaperoning and centrosome duplication. Aberrations involving nucleophasmin are found in multiple conditions, for instance in a form of non-Hodgkin lymphoma or acute promyelocytic leukemia. |
| Application Notes: | Mutations associated with nucleophasmin are present in varous conditions and this antibody has proven useful in different experiments investigating their molecular underpinnings. One group used NE24 antibody to perform immunohistochemical staining confirming that anaplastic large-cell lymphoma involves expression of mutated NPM-ALK fusion (Cordell et al., 1999). Finally, alterations of nucleophasmin expression were found in many cancers where this antibody might be utilised to analyse them. For example, Gimenez and colleagues (2010) performed immunohistochemical stainings and Western blot analyses to demonstrate aberrations in nucleophasmin expression in brain cancer. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |