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Mfg Part Number

Ab01325-23.0

Vector Labs Ab01325-23.0 Anti-S100 [S1-61], Rabbit IgG, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising BALB/c mice with S-100 protein, which was isolated from bovine brain andconjugated to BSA.

$517.40

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Description

Product Class: Purified
Clone ID: S1-61
Synonyms: S-100 protein; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1; S-100
Amount: 200 μg
Application Codes Clone: IHC; WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific against an epitope located on the alpha-chain of S100. S100 is a protein antigen present at certain cell types and useful in anatomy and pathology. It is capable of binding calcium and is similar to calmodulin but its exact function is unclear.
Application Notes: This antibody is useful in determining the presence of S100 protein marker which might be used to characterise various normal and malignant cells. S1-61 antibody was initially used to immunohistochemically label cells in different tissues, such as nerve, striated muscle and melanoma, among others (Vanstapel et al., 1986). Another group utilised it to immunohistochemically identify strongly S100-positive extensions of central nervous system tissue in the area of dorsal root entry zones in patient samples with Friedreich ataxia (Koeppen et al., 2017). This antibody was shown to be also effective in detecting S100 on Western blot - one group analysed S100 expression in liver cells subjected to the activity of exosomes containing tumour-derived miRNA (Zeng et al., 2018).

Product Class:	Purified
Clone ID:	S1-61
Synonyms:	S-100 protein; Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1; S-100
Amount:	200 μg
Application Codes Clone:	IHC; WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific against an epitope located on the alpha-chain of S100. S100 is a protein antigen present at certain cell types and useful in anatomy and pathology. It is capable of binding calcium and is similar to calmodulin but its exact function is unclear.
Application Notes:	This antibody is useful in determining the presence of S100 protein marker which might be used to characterise various normal and malignant cells. S1-61 antibody was initially used to immunohistochemically label cells in different tissues, such as nerve, striated muscle and melanoma, among others (Vanstapel et al., 1986). Another group utilised it to immunohistochemically identify strongly S100-positive extensions of central nervous system tissue in the area of dorsal root entry zones in patient samples with Friedreich ataxia (Koeppen et al., 2017). This antibody was shown to be also effective in detecting S100 on Western blot - one group analysed S100 expression in liver cells subjected to the activity of exosomes containing tumour-derived miRNA (Zeng et al., 2018).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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