Vector Labs Ab01335-13.12 Anti-CD68 [Y1/82A], Human IgG4-S228P, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: Y1/82A
Synonyms: Macrosialin; Gp110; DKFZp686M18236; SCARD1; scavenger receptor class D, member 1; SRD1; SR-D1; CD68 molecule; CD68 antigen; Macrophage Antigen CD68
Amount: 200 μg
Application Codes Clone: IHC; IF; FACS; WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognises human CD68 antigen. The Y1/82A antibody recognises an epitope distinct from those of antibody clones Y2/131, EBM11, Ki-M6 and KP1. Y1/82A is reportedly more specific for monocytes and macrophages than KP1. Its antigen, CD68 is a membrane glycoprotein highly expressed in monocytes and macrophages. It is involved in phagocytosis, lysosomal metabolism and interactions with pathogens and other cells.
Application Notes: This antibody was demonstrated to react with peripheral blood and bone marrow monocytes and resident macrophages in all tissues tested and was also able to characterise certain leukemias (Davey et al., 1988). Furthermore, it was proposed that Y1/82A may be useful in the diagnosis of monocytic leukaemias and histiocytic neoplasms as well as in the detection of macrophages in various diseases (Davey et al., 1988). For instance, one group utilised it during flow cytometric description of the expression of various surface markers on 1A1 and C06 cells in a study on microglia during HIV infection (Garcia-Mesa et al., 2017). Similarly, another group used this antibody to characterise vesicle cells during Varicella-Zoster Virus infection (Carpenter et al., 2011).

Product Class:	Purified
Clone ID:	Y1/82A
Synonyms:	Macrosialin; Gp110; DKFZp686M18236; SCARD1; scavenger receptor class D, member 1; SRD1; SR-D1; CD68 molecule; CD68 antigen; Macrophage Antigen CD68
Amount:	200 μg
Application Codes Clone:	IHC; IF; FACS; WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognises human CD68 antigen. The Y1/82A antibody recognises an epitope distinct from those of antibody clones Y2/131, EBM11, Ki-M6 and KP1. Y1/82A is reportedly more specific for monocytes and macrophages than KP1. Its antigen, CD68 is a membrane glycoprotein highly expressed in monocytes and macrophages. It is involved in phagocytosis, lysosomal metabolism and interactions with pathogens and other cells.
Application Notes:	This antibody was demonstrated to react with peripheral blood and bone marrow monocytes and resident macrophages in all tissues tested and was also able to characterise certain leukemias (Davey et al., 1988). Furthermore, it was proposed that Y1/82A may be useful in the diagnosis of monocytic leukaemias and histiocytic neoplasms as well as in the detection of macrophages in various diseases (Davey et al., 1988). For instance, one group utilised it during flow cytometric description of the expression of various surface markers on 1A1 and C06 cells in a study on microglia during HIV infection (Garcia-Mesa et al., 2017). Similarly, another group used this antibody to characterise vesicle cells during Varicella-Zoster Virus infection (Carpenter et al., 2011).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

Reviews