Mfg Part Number
Ab01336-13.12
Vector Labs Ab01336-13.12 Anti-CD45RB [PD7/26], Human IgG4-S228P, kappa (200 μg)
Quick Overview
This antibody was raised by immunising Balb/c mice with cells from a human peripheral-blood lymphocyte line maintained in T-cell growth factor.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | PD7/26 |
| Synonyms: | Receptor-type tyrosine-protein phosphatase C; PTPRC; Leukocyte common antigen; L-CA; T200; CD45; CD45R; LY5; T200 glycoprotein; T200 leukocyte common antigen |
| Amount: | 200 μg |
| Application Codes Clone: | IHC; IF; FACS; WB |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognises CD45RB which is a transmembrane tyrosine phosphatase that is present on all leukocytes and regulates the threshold of T cell antigen receptor signaling. There are multiple CD45R isoforms resulting from the alternative splicing of this gene. PD7/26 antibody binds to the exon 5. |
| Application Notes: | This antibody has been widely used in the identification of leukocytes (as CD45 is a pan-leukocyte marker) and lymphatic tumours in paraffin-embedded tissue sections. For instance, one group utilised it during the morphological characterisation of patient-derived xenografts via immunohistochemical staining of formalin-fixed, paraffin-embedded samples (Chijiwa et al., 2015). Another group used this antibody for immunofluorescence staining of similarly prepared fibroblast samples in chronic obstructive pulmonary disease (Brand et al., 2015). Finally, Deckert-Schlüter and colleagues (1998) used PD7/26 antibody when researching primary CNS lymphomas. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |