Vector Labs Ab01338-10.3 Anti-CD31 [JC70], Human IgG1, Fc Silent™, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: JC70
Heavy Chain Modification: Fc Silent™
Synonyms: PECAM1; Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; JC/70A
Amount: 200 μg
Application Codes Clone: IHC; IF; FACS; WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognises CD31 (PECAM1) which is a member of the immunoglobulin superfamily and is expressed at various circulatng cells, such as neutrophils, monocytes, platelets as well as on endothelial cells. CD31 is a cell adhesion molecule and is involved in the leukocyte transendothelial migration during inflammation.
Application Notes: This antibody recognises CD31 which is widely expressed on endothelial cells (Parums et al., 1990) and JC70 is a good marker of endothelial cells in paraffin sections. It may be used in the identification and characterisation of benign and malignant human vascular disorders (Parums et al., 1990). For instance, one group utilised this antibody to analyse formalin-fixed paraffin-embedded rat heart tissue in a study investigating relation between cisplatin and oxidative stress (Stojic et al., 2018). Similarly, another group labelled pancreatic tumour tissue samples against CD31 while studying factors influencing development of pancreatic cancer-associated thrombosis (Woei-A-Jin et al., 2016). Finally, Kandemir and colleagues (2012) stained formalin-fixed and paraffin-embedded samples of cutaneous Kaposi sarcoma in order to characterise its immunohistochemical profile.

Product Class:	Purified
Clone ID:	JC70
Heavy Chain Modification:	Fc Silent™
Synonyms:	PECAM1; Platelet endothelial cell adhesion molecule; PECAM-1; EndoCAM; GPIIA'; PECA1; JC/70A
Amount:	200 μg
Application Codes Clone:	IHC; IF; FACS; WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognises CD31 (PECAM1) which is a member of the immunoglobulin superfamily and is expressed at various circulatng cells, such as neutrophils, monocytes, platelets as well as on endothelial cells. CD31 is a cell adhesion molecule and is involved in the leukocyte transendothelial migration during inflammation.
Application Notes:	This antibody recognises CD31 which is widely expressed on endothelial cells (Parums et al., 1990) and JC70 is a good marker of endothelial cells in paraffin sections. It may be used in the identification and characterisation of benign and malignant human vascular disorders (Parums et al., 1990). For instance, one group utilised this antibody to analyse formalin-fixed paraffin-embedded rat heart tissue in a study investigating relation between cisplatin and oxidative stress (Stojic et al., 2018). Similarly, another group labelled pancreatic tumour tissue samples against CD31 while studying factors influencing development of pancreatic cancer-associated thrombosis (Woei-A-Jin et al., 2016). Finally, Kandemir and colleagues (2012) stained formalin-fixed and paraffin-embedded samples of cutaneous Kaposi sarcoma in order to characterise its immunohistochemical profile.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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