Vector Labs Ab01344-23.0 Anti-CD8a [C8/144B], Rabbit IgG, kappa (200 μg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: C8/144B
Synonyms: Leu2; CD8; CD8A; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; CD8a; p32
Amount: 200 μg
Application Codes Clone: IHC; IF; IP; WB
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognises alpha chain of human CD8 (CD8a). CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). CD8 is a T-cell co-receptor involved in the recognition of MHC class I molecules. It is present on cytotoxic/suppressor T lymphocytes.
Application Notes: Tis anti-CD8 antibody can be used to detect suppressor/cytotoxic T-cells and their neoplastic counterparts in tissue sections (van Gool et al., 2015). C8/144B has been extensively applied in multiple studies where the detection of CD8+ lymphocytes was needed, such as characterisation of various inflammatory diseases, cancer treatment etc. (Petukhova et al., 2010; Stover et al., 2018). For mature T-cells, presence of CD8 and CD4 is mutually exclusive, and thus using this anti-CD8 antibody with another one diected against CD4 might serve a way of distinguishing between different T-cell subpopulation. Furthermore, C8/144B antibody can be utilised in the identification of certain neoplasms when presence or absence of the anti-CD4 signal is of a diagnostic value. For example, in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed.

Product Class:	Purified
Clone ID:	C8/144B
Synonyms:	Leu2; CD8; CD8A; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; CD8a; p32
Amount:	200 μg
Application Codes Clone:	IHC; IF; IP; WB
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognises alpha chain of human CD8 (CD8a). CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). CD8 is a T-cell co-receptor involved in the recognition of MHC class I molecules. It is present on cytotoxic/suppressor T lymphocytes.
Application Notes:	Tis anti-CD8 antibody can be used to detect suppressor/cytotoxic T-cells and their neoplastic counterparts in tissue sections (van Gool et al., 2015). C8/144B has been extensively applied in multiple studies where the detection of CD8+ lymphocytes was needed, such as characterisation of various inflammatory diseases, cancer treatment etc. (Petukhova et al., 2010; Stover et al., 2018). For mature T-cells, presence of CD8 and CD4 is mutually exclusive, and thus using this anti-CD8 antibody with another one diected against CD4 might serve a way of distinguishing between different T-cell subpopulation. Furthermore, C8/144B antibody can be utilised in the identification of certain neoplasms when presence or absence of the anti-CD4 signal is of a diagnostic value. For example, in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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