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Mfg Part Number

Ab01366-2.3-VXS

Vector Labs Ab01366-2.3-VXS Anti-CD226 [10E5], Mouse IgG2a, Fc Silent™, kappa (1 mg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunising Lewis and Lou/M rats with the murine Th1 cell clone AE7 and Th1 cell lines derived from 5B6 and DO11.10 TCR transgenic mice, before screening for reactivity with Th1 clones and a lack of reactivity to Th2/Th0 cell lines.

$487.50

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Description

Product Class: VivopureX
Clone ID: 10E5
Heavy Chain Modification: Fc Silent™
Synonyms: DNAM-1; PTA1; PTA-1; platelet and T cell activation antigen 1; TLISA1
Amount: 1 mg
Application Codes Clone: FC
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: IgG2b
Storage Temperature: All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions. Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody is specific for murine CD226.
Application Notes: The specificity of this antibody for murine CD226 has been confirmed in flow cytometric analysis using 293 cells transfected with CD226 cDNA and untransfected 293 cells (Dardalhon et al, 2005). This antibody has been used in flow cytometry to identify the surface expression pattern of CD226, which is predominantly confined to T cells (Dardalhon et al, 2005; Yasuma et al, 2016), and to detect NK cell CD226 expression and apoptosis (Huang et al, 2011). Immunisation of mice with this antibody inhibits antigen-specific T cell expansion (Dardalhon et al, 2005). Additionally, treatment of experimental autoimmune encephalomyelitis (EAE) mice with this antibody delays the onset and reduces the severity of Th1 cell-mediated autoimmune disease (Dardalhon et al, 2005).

Product Class:	VivopureX
Clone ID:	10E5
Heavy Chain Modification:	Fc Silent™
Synonyms:	DNAM-1; PTA1; PTA-1; platelet and T cell activation antigen 1; TLISA1
Amount:	1 mg
Application Codes Clone:	FC
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	IgG2b
Storage Temperature:	All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions. Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2b format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody is specific for murine CD226.
Application Notes:	The specificity of this antibody for murine CD226 has been confirmed in flow cytometric analysis using 293 cells transfected with CD226 cDNA and untransfected 293 cells (Dardalhon et al, 2005). This antibody has been used in flow cytometry to identify the surface expression pattern of CD226, which is predominantly confined to T cells (Dardalhon et al, 2005; Yasuma et al, 2016), and to detect NK cell CD226 expression and apoptosis (Huang et al, 2011). Immunisation of mice with this antibody inhibits antigen-specific T cell expansion (Dardalhon et al, 2005). Additionally, treatment of experimental autoimmune encephalomyelitis (EAE) mice with this antibody delays the onset and reduces the severity of Th1 cell-mediated autoimmune disease (Dardalhon et al, 2005).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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