Mfg Part Number
Ab01465-23.0
Vector Labs Ab01465-23.0 Anti-CD4, Cytoplasmic tail [10C12], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was raised against a multiple antigenic peptide; a tetramer linked through a lysine backbone.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 10C12 |
| Synonyms: | Leu3/T4; 024; CD4 cytoplasmic tail; T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3 |
| Amount: | 200 μg |
| Application Codes Clone: | ELISA; IF; WB; blocking |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognises LSEKKTCQCPHRFQKTCSPI peptide of human CD4 epitope within amino acids 414 and 433 of the cytoplasmic tail region. CD4 is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus.The cytoplasmic tail region transmits a signal in response to p56-lck. HIV nef is also known to interact with the cytoplasmic tail of CD4. |
| Application Notes: | 10C12 antibody reacts with a poorely studied tail region of human CD4 and might be used to conduct reasearch on the role of this fragment of the protein. Furthermore, this antibody can be used for studies on expression of CD4. One group utilised 10C12to perform Western blot analysis of CD4 expression in cerebellar granule neurons when researching interleukin-16 induced c-Fos expression (Fenster et al., 2010). This antibody may be also used as an effective blocking agent inhibiting Il-16 (Atanackovic et al., 2012). Finally, 10C12 has also been recommended for studies of the role of selenium metabolism and selenoproteins in diseases, such as infectious diseases (HIV) and cancer (Ware, 2003). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |