Mfg Part Number
Ab01491-2.0-VXL
Vector Labs Ab01491-2.0-VXL Anti-CD115/M-CSFR [AFS98], Mouse IgG2a, kappa (10 mg)
Quick Overview
This antibody was raised against CD115.
$2,013.70
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| Product Class: | VivopureX |
|---|---|
| Clone ID: | AFS98 |
| Synonyms: | CSF-1R; Macrophage colony-stimulating factor 1 receptor; Csf1r; CD115; CSF-1 receptor; EC 2.7.10.1; CSF-1-R; M-CSF-R; Proto-oncogene c-Fms |
| Amount: | 10 mg |
| Application Codes Clone: | FC; blocking; WB; IHC |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS only. |
| Original Format: | IgG2a |
| Storage Temperature: | All VivopureX products are formulated in PBS only without addition of preservatives. To ensure optimal storage and prevent microbial contamination, only open and dispense under sterile conditions. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognises mouse M-CSFR (CD115, CSF-1R) which is a membrane protein that influences tissue macrophage and osteoclast differentiation and proliferation. |
| Application Notes: | AFS98 has been widely used in various flow cytometric analyses to label CD115 antigen. For instance, one group used it to detect monocytes in a mouse blood sample (Buschor et al., 2019). Similarly, Huo and colleagues (2017) utilised this antibody to identify monocytes in mouse blood in order to assess whether myelopoiesis was not a cause of the increase in the monocytes number. This antibody has been also successfully used to deplete macrophages (Ho et al., 2016). Finally, it was also utilised in the immunofluorescence staining of tissue sections prepared from 4% paraformaldehyde-fixed and decalcified bones (Dong et al., 2016). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |