Mfg Part Number
Ab01543-10.0
Vector Labs Ab01543-10.0 Anti-CD59 [193-27], Human IgG1, kappa (200 μg)
Quick Overview
This antibody was raised by immunizng mice with stimulated human leukocytes.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 193-27 |
| Synonyms: | 1F5; 1F5 antigen; CD59 glycoprotein; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IHC; IF |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgM |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgM format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes human CD59 which is a glycosyl phosphatidyl-inositol (GPI)-anchored cell surface protein. It regulates complement-mediated cell lysis, and is involved in lymphocyte signal transduction. |
| Application Notes: | The antibody 193-27 is recommended for the identification and analysis of CD59 via various experimental techniques (Bellosillo et al., 2001). Genetic defects in GPI-anchor attachment, that cause a reduction or loss of CD59 and CD55 on erythrocytes produce the symptoms of the disease paroxysmal hemoglobinuria (PNH) and thus this antibody is useful for study on GPI-anchored proteins, PNH and CD59 functions. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |