Mfg Part Number
Ab01553-23.0
Vector Labs Ab01553-23.0 Anti-IgNAR [GA8], Rabbit IgG, kappa (200 μg)
Quick Overview
This antibody was raised by immunising mice with nurse shark IgNAR.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | GA8 |
| Synonyms: | Shark HC antibody; Immunoglobulin new antigen receptor; immunoglobulin novel antigen receptor; novel antigen receptor; NAR; Q8AXH5; Q90544 |
| Amount: | 200 μg |
| Application Codes Clone: | IP; IHC; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific for IgNAR, an Ig heavy chain isotype specific to elasmobranchs, and reacts with an epitope in the constant domain. This anti-nurse shark IgNAR antibody has been shown to cross-react with spiny dogfish IgNAR. |
| Application Notes: | This antibody immunoprecipitates IgNAR from both nurse shark and spiny dogfish plasma (Smith et al, 2012), and from serum and yolk extracts from mature unfertilized nurse shark eggs (Haines et al, 2005). This antibody has been used in immunohistochemical analysis of IgNAR expression in frozen sections of nurse shark spleen, to identify its cellular organisation (Rumfelt et al, 2002). This antibody has been used in ELISA analysis to measure plasma titres of IgNAR following spiny dogfish immunisation with human serum albumin (Muller et al, 2012) and nurse shark immunisation with human and murine induced costimulatory ligand (Kovaleva et al, 2017) and with recombinant human TNF-α (Ubah et al, 2017). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |