Mfg Part Number
Ab01575-10.3
Vector Labs Ab01575-10.3 Anti-C5aR [S5/1], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunizing mice with a synthetic peptide corresponding to C5a-R; amino acids: 1-31 (N terminal).
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | S5/1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD88; C5a anaphylatoxin chemotactic receptor; C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR |
| Amount: | 200 μg |
| Application Codes Clone: | blocking; WB; FC; IP; ELISA; functional studies |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | S5/1 antibody recognizes the C5aR (CD88) protein, a 43 kDa receptor of C5a component of the complement cascade. |
| Application Notes: | S5/1 antibody inhibits C5a binding to its receptor C5aR (Oppermann et al., 1993). Furthermore, this antibody has been widely applied in the detection and analysis of C5aR via various methods. For instance, it was used in a flow cytometric study on peripheral blood lymphocytes where it was shown to bind to monocytes and granulocytes (Oppermann et al., 1993). It was also utilized in the Western blot experiments comparing C5aR expression in different groups of mice (Panayiotou et al., 2017). S5/1 was also successfull in labelling C5aR in the paraffin-embedded immunohistochemical samples of umbilical arteries (Fortin et al., 2002). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |