Mfg Part Number
Ab01587-10.3
Vector Labs Ab01587-10.3 Anti-Beta 2 adrenergic receptor [13D6], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunizing mice with beta-2 adrenergic receptor.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 13D6 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | R11E1; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor; β-2 adrenergic receptor; β-2 adrenoreceptor; β-2 adrenoceptor; β2AR; β2-AR; I3D6 |
| Amount: | 200 μg |
| Application Codes Clone: | WB; IP; IF; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | 13D6 antibody recognizes human beta-2 adrenergic receptor. It was reported that this antibody recognizes extracellualr domains of the receptor (Han et al., 2012). Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds adrenaline with far grater affinity than noradrenaline. |
| Application Notes: | This antibody is recommended for the identification and analysis of the β2-adrenergic receptor. For instance, tt was used to immunostain vascular smooth muscle cells (VSMCs) against beta-2-adrenergic receptor to determine the fate of beta-2ARs ubiquitinated in a carvedilol responsive manner (Han et al., 2012). Furthermore, the antibody was utilized in the quantification of the surface level of β-2ARs via ELISA (Han et al., 2012). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |