Mfg Part Number
Ab01590-3.3
Vector Labs Ab01590-3.3 Anti-CCR7 [4B12], Mouse IgG2b, Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunizing rats with mouse CCR7 antigen.
$517.40
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | 4B12 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | EBI1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus-induced G-protein coupled receptor 1; MIP-3 beta receptor; CD197; C-C CKR-7; CC-CKR-7; C-C chemokine receptor type 7 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; IP; functional assays |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Rat IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody is specific to the mouse CCR7 protein, which was confirmed by immunoprecipitation (Ritter et al, 2004). |
| Application Notes: | This antibody was used for flow cytometry and the staining quality can be improved by incubation at 37°C (Britschgi et al, 2008). This antibody is widely used to monitor the activation of dendritic cells in mice (Ohl et al, 2004; Ritter et al, 2004; Zhao et al, 2019). It was also utilized in immunoprecipitation of the CCR7 receptor protein (Ritter et al, 2004). The antibody does not interfere with ligands binding to the CCR7 receptor, which was confirmed by a transmigration assay (Ritter et al, 2004). It does not interfere with T-cell migration (Ritter et al, 2004). The antibody also is not agonistic as it does not activate the receptor (Ritter et al, 2004). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |