Mfg Part Number
Ab01609-2.0
Vector Labs Ab01609-2.0 Anti-Complement C3b-iC3b [5G9], Mouse IgG2a, kappa (200 μg)
Quick Overview
The original version of this antibody was created by immunizing a mouse with complement C3b-iC3b.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 5G9 |
| Synonyms: | Complement C3; C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; Complement C3 beta chain; C3-beta-c; C3bc; Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein; ASP; C3adesArg; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2 |
| Amount: | 200 μg |
| Application Codes Clone: | functional assays; blocking; FC; neutralizing |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Specificity Statement: | This antibody is specific for complement C3b-iC3b. C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. |
| Application Notes: | This antibody has been shown to inhibit the CPC-mediated lysis of PNH erythrocytes in humans (Lindorfer et al, 2016; pmid:20068220). A CDC assay was preformed using this antibody on human Burkitt’s lymphoma cell lines, Daudi, Raji, Z138 mantle cell lymphoma cell lines and diffuse large B cell lymphoma cell line SU-DHL-4 (Beurskens et al, 2012; pmid:22368276). This antibody can also be used for flow cytometry and neutralizing applications. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |