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Mfg Part Number

Ab01658-10.3

Vector Labs Ab01658-10.3 Anti-desmoglein-2 [6D8], Human IgG1, Fc Silent™, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was raised by immunizing mice with a recombinant human full-length DSG2 protein.

$517.40

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Description

Product Class: Purified
Clone ID: 6D8
Heavy Chain Modification: Fc Silent™
Synonyms: Cadherin family member 5; Desmoglein 2; HDGC; DSG2; 3G132
Amount: 200 μg
Application Codes Clone: WB; FC; IF; IHC; IP
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody recognizes human desmoglein-2. This clone does not cross-react with Desmoglein 1 or Desmoglein 3. The epitope is within the extracellular domain (EC3/EC4) of Desmoglein 2/DSG2. Desmoglein-2 is part of a cadherin protein family and is involved in the creation of desmosomes.
Application Notes: The antibody 6D8 has been used successfully to identify and analyse desmoglein-2 via various methods. For instance, it was utilized to label desmoglein 2 in melanoma tissue samples via immunohistochemistry to investiagete expression pattern of DSG2 in this cancer (Tan et al., 2016; pmid: 27340778). Furthermore, this antibody was also used to label DSG2 during flow cytometric analysis of cells (Tan et al., 2016; pmid: 27340778). The antibody 6D8 has also been applied in a Western blot detection of desmogleins in transfected A-431D cells (Wahl, 2002; pmid: 11991815). Finally, this antibody immunoprecipitated desmoglein-a from A-431 cell extracts prepared in 0.1% Empigen BB (Wahl, 2002; pmid: 11991815).

Product Class:	Purified
Clone ID:	6D8
Heavy Chain Modification:	Fc Silent™
Synonyms:	Cadherin family member 5; Desmoglein 2; HDGC; DSG2; 3G132
Amount:	200 μg
Application Codes Clone:	WB; FC; IF; IHC; IP
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody recognizes human desmoglein-2. This clone does not cross-react with Desmoglein 1 or Desmoglein 3. The epitope is within the extracellular domain (EC3/EC4) of Desmoglein 2/DSG2. Desmoglein-2 is part of a cadherin protein family and is involved in the creation of desmosomes.
Application Notes:	The antibody 6D8 has been used successfully to identify and analyse desmoglein-2 via various methods. For instance, it was utilized to label desmoglein 2 in melanoma tissue samples via immunohistochemistry to investiagete expression pattern of DSG2 in this cancer (Tan et al., 2016; pmid: 27340778). Furthermore, this antibody was also used to label DSG2 during flow cytometric analysis of cells (Tan et al., 2016; pmid: 27340778). The antibody 6D8 has also been applied in a Western blot detection of desmogleins in transfected A-431D cells (Wahl, 2002; pmid: 11991815). Finally, this antibody immunoprecipitated desmoglein-a from A-431 cell extracts prepared in 0.1% Empigen BB (Wahl, 2002; pmid: 11991815).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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