Mfg Part Number
Ab01663-10.3
Vector Labs Ab01663-10.3 Anti-SARS-CoV S glycoprotein [6B1], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing a non human transgenic animal XENOMOUSE® IgG2k mice against S1 protein-Ig fragments (ectodomain) of the S Protein (Tor2).
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| Product Class: | Purified |
|---|---|
| Clone ID: | 6B1 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Spike protein; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1 |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This reformatted human antibody was made using the variable domain sequences of the original Human IgG2 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody specifically binds the amino acids 318-510 in the S1 domain of the SARS-CoV Spike protein (Urbani strain). |
| Application Notes: | This antibody inhibits the association of SARS-CoV s protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus. The originally characterized antibody had has a neutralizing titer 200TCID50 of 3.125 μg/ml (Coughlin et at.,2006) and IC50 of 4.08μg/ml when incubated with S12–510- Fc recombinant protein (Coughlin et at.,2009). This antibody 6B1 showed about 50% binding to Sin845 S1 protein relative to their binding to Urbani S1 protein. GZ0402-S1 protein showed minimal of 52% binding to HmAbs 6B1 (Elshabrawy et al., 2012). Other applications include ELISA. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |