Mfg Part Number
Ab01667-3.3
Vector Labs Ab01667-3.3 Anti-SARS-CoV S glycoprotein [11A], Mouse IgG2b, Fc Silent™, lambda (200 μg)
Quick Overview
The original antibody was produced by panning against GD03-RBD-C9, two non-immune human Ab phage display libraries and neutralizing activity was tested against pseudotyped viruses.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 11A |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Spike protein; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1 |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric mouse antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody specifically binds the amino acids 472 and 480 in the S1 domain of the SARS-CoV Spike protein (GD03). |
| Application Notes: | This antibody inhibits the association of SARS-CoV S protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus strain GD03. 11A potently inhibited GD03-RBD’s binding to ACE2 expressing 293T cells. Kinetic analysis of 11A IgG binding to GD03-RBD demonstrated high affinity interaction (KD = 2.260.7 nM). Single amino acid changes at either position D480A or D480G resulted in complete loss of 11A binding. (Sui et al., 2008) |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |