Mfg Part Number
Ab01668-23.0
Vector Labs Ab01668-23.0 Anti-SARS-CoV S glycoprotein [256], Rabbit IgG, lambda (200 μg)
Quick Overview
The original antibody was produced by panning against GD03-RBD-C9, two non-immune human Ab phage display libraries and neutralizing activity was tested against pseudotyped viruses.
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| Product Class: | Purified |
|---|---|
| Clone ID: | 256 |
| Synonyms: | Spike protein; S protein; SARS-CoV S protein; S glycoprotein; E2; Peplomer protein; Spike protein S1 |
| Amount: | 200 μg |
| Application Codes Clone: | NTRL; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody specifically binds the amino acids 472 and 480 in the S1 domain of the SARS-CoV Spike protein (Tor2 and GD03). |
| Application Notes: | This antibody inhibits the association of SARS-CoV S protein to the angiotensin-converting enzyme 2 (ACE2) receptor by binding to specific amino acids on the S1 domain of the spike protein of the virus. 256-IgG1 was capable of neutralizing both the mutations of the spike protein at D480A and D480G. It also neutralized Tor2 and marginally neutralized GD03. Neither of the antibodies 11A nor 80R competed with 256 IgG1 for binding to Tor2 suggesting that the binding epitope of 256 was different from that of 80R and 11A (Sui et. al, 2008) |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |