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Mfg Part Number

Ab01685-3.0

Vector Labs Ab01685-3.0 Anti-CD40 [chi220], Mouse IgG2b, kappa (200 μg)

VECTOR LABS

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Quick Overview

This antibody was generated by immunizing female BALB/c mice with a fusion protein containing extracellular domain of human CD40 fused to the hinge CH2 and CH3 domains of a murine IgG2b antibody.

$517.40

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Description

Product Class: Purified
Clone ID: chi220
Synonyms: TNFSF5; CDw40; TRAP; p50; Bp50; CD40L receptor; Tumor necrosis factor ligand superfamily member 5; B-cell surface antigen CD40; T-cell antigen Gp39; TNF-related activation protein.
Amount: 200 μg
Application Codes Clone: Block; Therapeutic
Shipping Temperature: Wet Ice
Buffer Composition: PBS with 0.02% Proclin 300.
Original Format: IgG2a
Storage Temperature: Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement: This antibody binds the CD40 and blocks the humoral immune responses to T cell dependent antigens in a dose dependent manner.
Application Notes: This antibody blocks the interaction between CD40 and gp39. Chi220 was used either alone or in combination with CTLA4-Ig in an immunosuppresive therapy study to check the survival of renal allografts in non human primate models (PMID: 12394833). Chi220 blocks binding of CD154, it also has partial agonist properties and weak stimulatory potential. It synergisticaly works with LEA29Y (belatacept) to prolong the islet allograft survival in a non-human primate Macaca fascicularis (PMID: 15611281). A study on protection of islets xenographs in diabetic macaques used a combination of Chi220 with IL-2 receptor specific antibody Basiliximab for immunosuppression with induction therapy. Chi220 is used as an sCD154 blocking agent and it was seen that it binds sCD154 in a dose dependant manner (PMID: 21920020). Two humanized versions of this antibody were generated F4 and L3.17, also showed similar properties. Humanized versions of this antibody are available on request.

Product Class:	Purified
Clone ID:	chi220
Synonyms:	TNFSF5; CDw40; TRAP; p50; Bp50; CD40L receptor; Tumor necrosis factor ligand superfamily member 5; B-cell surface antigen CD40; T-cell antigen Gp39; TNF-related activation protein.
Amount:	200 μg
Application Codes Clone:	Block; Therapeutic
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS with 0.02% Proclin 300.
Original Format:	IgG2a
Storage Temperature:	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
Specificity Statement:	This antibody binds the CD40 and blocks the humoral immune responses to T cell dependent antigens in a dose dependent manner.
Application Notes:	This antibody blocks the interaction between CD40 and gp39. Chi220 was used either alone or in combination with CTLA4-Ig in an immunosuppresive therapy study to check the survival of renal allografts in non human primate models (PMID: 12394833). Chi220 blocks binding of CD154, it also has partial agonist properties and weak stimulatory potential. It synergisticaly works with LEA29Y (belatacept) to prolong the islet allograft survival in a non-human primate Macaca fascicularis (PMID: 15611281). A study on protection of islets xenographs in diabetic macaques used a combination of Chi220 with IL-2 receptor specific antibody Basiliximab for immunosuppression with induction therapy. Chi220 is used as an sCD154 blocking agent and it was seen that it binds sCD154 in a dose dependant manner (PMID: 21920020). Two humanized versions of this antibody were generated F4 and L3.17, also showed similar properties. Humanized versions of this antibody are available on request.

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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