Mfg Part Number
Ab01701-201.4
Vector Labs Ab01701-201.4 Anti-ICOS [3F12], Dog IgG2 (IgG-B), Fc Silent™, kappa (200 μg)
Quick Overview
This antibody was raised by immunizing RBF/DnJ mice with caICOS-murine-IgG2a fusion and hybridomas were generated using accepted methods.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 3F12 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD278; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; Inducible co-stimulator; Inducible costimulator; caICOS; canine ICOS; dog ICOS |
| Amount: | 200 μg |
| Application Codes Clone: | FC; blocking; ELISA |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG2a |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric dog antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody specifically recognizes canine ICOS, which enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. |
| Application Notes: | 3F12 can be used to identify canine ICOS and analyse its activity. The antibody is an antagonist of ICOS and exhibits the ability to significantly suppress mixed leukocyte reactions (MLR) (Sato et al., 2013; pmid: 23694952). Anti-ICOS antibody was also shown to be an effective agent that can be used in the treatment development of Canine Chronic Graft-versus-Host Disease (GVHD) (Graves et al., 2017; pmid: 28958896). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |