Mfg Part Number
Ab02031-10.3
Vector Labs Ab02031-10.3 Anti-NKG2D [11B2D10], Human IgG1, Fc Silent™, kappa (200 μg)
Quick Overview
The original antibody was generated by immunizing BALB/c mice with soluble NKG2-D fragments containing amino acids from 64-462 and 123-462.
$517.40
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| Product Class: | Purified |
|---|---|
| Clone ID: | 11B2D10 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | CD314; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; KLRK1 |
| Amount: | 200 μg |
| Application Codes Clone: | FC; blocking |
| Shipping Temperature: | Wet Ice |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This chimeric human antibody was made using the variable domain sequences of the original Mouse IgG1 format, for improved compatibility with existing reagents, assays and techniques. |
| Specificity Statement: | This antibody recognizes and binds the extracellular epitope of NKG2D and blocks the interaction between ligand and receptor. |
| Application Notes: | The NKG2D (Natural Killer Group 2 Member D) protein is an activating receptor that enables NK and CD8+ T cells to recognize and eliminate infected or transformed endogenous cells. However, incorrect regulation of this receptor on immune cells also appears to lead to the development of autoimmune diseases such as type I diabetes, celiac disease, and RA. This antibody positively reacts with NKG2D on CD8-positive T cells and to CD56-positive natural killer cells. The binding was confirmed by FACS analysis (Steigerwald, 2008). |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |